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morphology explorer bioapplication v4 hcs studio  (Thermo Fisher)


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    Thermo Fisher morphology explorer bioapplication v4 hcs studio
    Morphology Explorer Bioapplication V4 Hcs Studio, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/morphology explorer bioapplication v4 hcs studio/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    morphology explorer bioapplication v4 hcs studio - by Bioz Stars, 2026-03
    90/100 stars

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    Single-cell-based quantification of F-actin cytoskeletal structure. The multi-channel images were automatically captured using an Arrayscan VTI HCS reader with HCS Studio 2.0 Morphology Explorer BioApplication module (Thermo Fisher Scientific, Massachusetts). Cytoskeletal rearrangement analysis was conducted in the images obtained from the coculture model (A), and automatic segmentation of the nuclei images cells (blue line, B) and cellular outline (yellow line, C) were conducted. The localization and orientation of F-actin fibers were determined (C, green). A statistical summary of F-actin fibers was identified from bar charts and scatter plots (D). Actin fibers greater than a threshold length were identified and labeled with green, and the fiber intensity over 100 pixels were highlighted with red overlay (D), indicating F-actin bundle formation across cells in the coculture model.

    Journal: Toxicological Sciences

    Article Title: From the Cover: An Animal-Free In Vitro Three-Dimensional Testicular Cell Coculture Model for Evaluating Male Reproductive Toxicants

    doi: 10.1093/toxsci/kfx139

    Figure Lengend Snippet: Single-cell-based quantification of F-actin cytoskeletal structure. The multi-channel images were automatically captured using an Arrayscan VTI HCS reader with HCS Studio 2.0 Morphology Explorer BioApplication module (Thermo Fisher Scientific, Massachusetts). Cytoskeletal rearrangement analysis was conducted in the images obtained from the coculture model (A), and automatic segmentation of the nuclei images cells (blue line, B) and cellular outline (yellow line, C) were conducted. The localization and orientation of F-actin fibers were determined (C, green). A statistical summary of F-actin fibers was identified from bar charts and scatter plots (D). Actin fibers greater than a threshold length were identified and labeled with green, and the fiber intensity over 100 pixels were highlighted with red overlay (D), indicating F-actin bundle formation across cells in the coculture model.

    Article Snippet: The multi-channel images were automatically captured using an Arrayscan VTI HCS reader with HCS Studio 2.0 Morphology Explorer BioApplication module (Thermo Fisher Scientific, Massachusetts).

    Techniques: Labeling